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“A recent investigation comparing children who received twice-yearly azithromycin with children who received placebo found that the gut’s resistome, a reservoir of antimicrobial resistance genes in the body, had increased determinants of macrolide and nonmacrolide resistance, including beta-lactam antibiotics, among children receiving azithromycin (10). These adverse reactions differ from those reported with immediate release or the prolonged release formulations, either in kind or in frequency: Reporting suspected adverse reactions after authorisation of the medicinal product is important. No other adverse reactions occurred in patients on the multiple-dose regimens of azithromycin with a frequency greater than 1%.
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