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Azithromycin plus usual care (n=526) Usual care alone * (n=862) Total (n=1388) Age (years) 60·9 (7·9) 60·5 (7·8) 60·7 (7·8) Age by 5-year bands (years) 50–54 131 (25%) 236 (27%) 367 (26%) 55–59 130 (25%) 219 (25%) 349 (25%) 60–64 84 (16%) 123 (14%) 207 (15%) 65–69 108 (21%) 153 (18%) 261 (19%) 70–74 48 (9%) 90 (10%) 138 (10%) 75–79 13 (2%) 30 (3%) 43 (3%) 80–84 7 (1%) 8 (1%) 15 (1%) 85–89 4 (1%) 2 ( 6 ( 90–94 1 ( 1 ( 2 ( Sex Female 301 (57%) 486 (56%) 787 (57%) Male 224 (43%) 375 (44%) 599 (43%) Missing data 1 ( 1 ( 2 ( Comorbidity No 63 (12%) 102 (12%) 165 (12%) Yes 463 (88%) 760 (88%) 1223 (88%) Ethnicity † White 434 (83%) 700 (82%) 1134 (82%) Mixed background 10 (2%) 22 (3%) 32 (2%) South Asian 21 (4%) 34 (4%) 55 (4%) Black 2 ( 5 (1%) 7 (1%) Other 12 (2%) 9 (1%) 21 (2%) Missing data 47 (9%) 92 (11%) 139 (10%) Duration of illness before randomisation (days) 6 (4–9) [0–28] 6 (4–10) [0–63] ‡ 6 (4–10) [0–63] Smoking status Current smoker 62 (12%) 117 (14%) 179 (13%) Former smoker 187 (36%) 317 (37%) 504 (36%) Never smoker 264 (50%) 403 (47%) 667 (48%) Missing data 13 (2%) 25 (3%) 38 (3%) Swab result within 28 days of randomisation Negative 266 (51%) 439 (51%) 705 (51%) Positive 189 (36%) 245 (28%) 434 (31%) No result 2 ( 7 (1%) 9 (1%) Missing data 69 (13%) 171 (20%) 240 (17%) Asthma, chronic obstructive pulmonary disease, or lung disease 193 (37%) 329 (38%) 522 (38%) Diabetes 90 (17%) 162 (19%) 252 (18%) Heart problem § 86 (16%) 126 (15%) 212 (15%) High blood pressure for which medication is being taken 209 (40%) 368 (43%) 577 (42%) Liver disease 16 (3%) 23 (3%) 39 (3%) Stroke or other neurological problem 31 (6%) 52 (6%) 83 (6%) Taking angiotensin-converting enzyme inhibitor ¶ 103 (20%) 179 (21%) 282 (20%) Missing data 2 ( 4 ( 6 ( Fever at baseline No problem 222 (42%) 372 (43%) 594 (43%) Minor problem 164 (31%) 300 (35%) 464 (33%) Moderate problem 122 (23%) 168 (19%) 290 (21%) Major problem 18 (3%) 22 (3%) 40 (3%) Cough at baseline No problem 94 (18%) 155 (18%) 249 (18%) Minor problem 217 (41%) 335 (39%) 552 (40%) Moderate problem 175 (33%) 317 (37%) 492 (35%) Major problem 40 (8%) 55 (6%) 95 (7%) Shortness of breath at baseline No problem 205 (39%) 271 (31%) 476 (34%) Minor problem 212 (40%) 380 (44%) 592 (43%) Moderate problem 92 (17%) 192 (22%) 284 (20%) Major problem 17 (3%) 19 (2%) 36 (3%) Muscle ache at baseline No problem 164 (31%) 266 (31%) 430 (31%) Minor problem 193 (37%) 335 (39%) 528 (38%) Moderate problem 134 (25%) 194 (23%) 328 (24%) Major problem 35 (7%) 67 (8%) 102 (7%) Nausea at baseline No problem 392 (75%) 646 (75%) 1038 (75%) Minor problem 96 (18%) 182 (21%) 278 (20%) Moderate problem 32 (6%) 27 (3%) 59 (4%) Major problem 6 (1%) 7 (1%) 13 (1%) Feeling generally unwell (malaise) at baseline No problem 31 (6%) 44 (5%) 75 (5%) Minor problem 211 (40%) 291 (34%) 502 (36%) Moderate problem 206 (39%) 263 (31%) 469 (34%) Major problem 53 (10%) 38 (4%) 91 (7%) Missing data 25 (5%) 226 (26%) 251 (18%) Diarrhoea at baseline No problem 356 (68%) 477 (55%) 833 (60%) Minor problem 94 (18%) 110 (13%) 204 (15%) Moderate problem 38 (7%) 39 (5%) 77 (6%) Major problem 13 (2%) 10 (1%) 23 (2%) Missing data 25 (5%) 226 (26%) 251 (18%) Taken antibiotics since illness started 15 (3%) 37 (4%) 52 (4%) Missing data 1 ( 1 ( 2 ( Use of health-care services General practitioner 150 (29%) 243 (28%) 393 (28%) Other primary care services 26 (5%) 53 (6%) 79 (6%) UK National Health Service 111 86 (16%) 160 (19%) 246 (18%) Accident and emergency department 6 (1%) 14 (2%) 20 (1%) Other health-care services 47 (9%) 78 (9%) 125 (9%) WHO-5 Well-Being Index score 49·9 (25·4) 49·5 (24·2) 49·7 (24·7) Missing data 0 24 (3%) 24 (2%)
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